Model organisms in inflammation and cancer

Model organisms in inflammation and cancer

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A link between inflammation and cancer was initially made by Rudolf Virchow back in the 19th century. Nowadays many cancers are considered dependent on inflammatory responses to microbial and damaged-self stimuli and both arms of immunity, innate and adaptive, are playing a role in promoting cancer. Moreover, besides environmental factors, opportunistic pathogens contribute to inflammation and cancer. Nevertheless, microbial influence on chronic disease is sometimes difficult to discern, especially in the context of polymicrobial communities, such as those found in the digestive tract. In this light, model organisms provide important insights into immune and growth signals that promote cancer, and suggest therapies that will selectively target potentially harmful microbes or modulate host responses. A number of review and opinion articles in this series address novel aspects and paradigms of the interactions between the microbiota and the host in relation to inflammation and cancer.In a study to reveal the genetic and molecular networks in control of systemic wound response after physical wounding in ... microtubules and the CDC42 small GTPase which respond dynamically during wound repair (Abreu-Blanco et al., 2011, 2012). ... in the remodeling of actin cytoskeleton also actively participate in the larval wound healing (Lesch et al., 2010). ... Though potential signaling pathways were not the focus of this genome-wide analysis, the large number of genes to beanbsp;...

Title:Model organisms in inflammation and cancer
Author: Yiorgos Apidianakis, Dominique Ferrandon
Publisher:Frontiers E-books - 2014-12-17

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